Author's response to reviews Title: Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease Authors:
نویسندگان
چکیده
Malin E Andersson ([email protected]) Sara Landgren ([email protected]) Staffan Nilsson ([email protected]) Dragana Celojevic ([email protected]) Petra Bergström ([email protected]) Anna Håkansson ([email protected]) Hans Nissbrandt ([email protected]) Marek Drozdzik ([email protected]) Monika Bialecka ([email protected]) Mateusz Kurzawski ([email protected]) Kaj Blennow ([email protected]) Michael Nilsson ([email protected]) Ola Hammarsten ([email protected]) Henrik Zetterberg ([email protected])
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Nuclear factor erythroid 2-like 2 (NRF2) encodes a transcription factor regulating mechanisms of cellular protection and is activated by oxidative stress. NRF2 has therefore been hypothesized to confer protection against Parkinson's disease and so far an NRF2 haplotype has been reported to decrease the risk of developing disease and delay disease onset. Also NRF2 adopts a nuclear localization i...
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Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by a combination of genetic and environmental factors. The molecular mechanisms that underlie PD are unknown; however, oxidative stress and impairment of antioxidant defence mechanisms have been implicated as major contributors to disease pathogenesis. Previously, we have reported a PD patient-derived cellular model gen...
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